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Psoriasis Vol2 |
| The Psoriasis Theories |
| by Louise Forrest |
| |
No
one fully understands what causes yet, but doctors have several theories.
We have known for a long time that psoriasis seems to
run in families. This is not to say that if you have
the disease your children definitely will, or that if
your parents did not you will not either. Rather, there
is a marked increase in psoriasis among people whose
parents, grandparents or siblings have the disease.
If one spouse has psoriasis, a couple’s children
have a one-in-four chance of developing psoriasis too.
Although we have nailed down the numbers, dermatologists
and genetics experts still do not know exactly how psoriasis
is passed from one generation to the next, but we are
getting closer to an answer. Recent study of blood samples
has suggested to researchers that there are several
genes that transmit psoriasis. The exact locations of
the genes remain unknown, but scientists are currently
trying to identify them precisely. They may be able
to alter the way they affect people who are born with
them and also possibly lead to new . A greater understanding of the psoriasis genes may also help to select the ideal treatment for some patients.
Proper diagnosis of your psoriasis helps to assure
proper treatment. Many doctors who are not dermatologists
see very few patients with psoriasis. Your family
doctor may have difficulty in pinpointing the diagnosis,
which could lead to inappropriate treatment. That
is why it is important to consult a dermatologist
at the early stages of psoriasis.
Beyond understanding how psoriasis is inherited, researchers
have several theories as to how psoriasis actually develops
in people with a genetic predisposition to it. Recent
research suggests several different possible sites for
the psoriasis gene and there may well be several genes.
One theory is that a lack of control of the outer skin
cells leads to the greatly increased production of cells
that characterize psoriasis. This may result to an abnormality
of the blood vessels and the inflammation characteristic
of psoriasis. An all over should be considered to aid relief of the symptoms.
Other researchers feel that psoriasis patients have
an abnormality in the skin that leads to inflammation.
This inflammation leads to a buildup of white blood
cells from the blood. This buildup of white blood
cells then triggers the thickened skin of psoriasis.
Still another possibility is that the epidermal skin
cells fail to mature into the flat, thickened cornified
layer they are supposed to. As a result, the epidermis
tries to produce more cells than usual, leading to
the thickened epidermis; this then leads to inflammation.
Many patients find that symptoms vary over time.
The various reasons are firstly, infections may prompt
or worsen psoriasis. For example, guttate psoriasis
sometimes flares up in patients who are sensitive
to bacterial sore throats. Some people may get severe
psoriasis on the skin fold and scalp as a result of
a yeast infection in the skin. Stress has also been
named as a major culprit in psoriasis flare ups. Fortunately,
counseling and relaxation techniques can go a long
way towards minimizing the stress trigger and can
be very helpful in keeping psoriasis under control. |
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